Pub. Date : 2018 May
PMID : 30603055
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Neoadjuvant administration of hydroxychloroquine in a phase 1 clinical trial induced plasma Par-4 levels and apoptosis in diverse tumors. | Hydroxychloroquine | Prader Willi/Angelman region RNA 4 | Homo sapiens |
| 2 | Chloroquine and hydroxychloroquine (HCQ) are robust inducers of the tumor suppressor Par-4 secretion from normal cells. | Hydroxychloroquine | Prader Willi/Angelman region RNA 4 | Homo sapiens |
| 3 | Chloroquine and hydroxychloroquine (HCQ) are robust inducers of the tumor suppressor Par-4 secretion from normal cells. | Hydroxychloroquine | Prader Willi/Angelman region RNA 4 | Homo sapiens |
| 4 | Eight of the nine patients treated with HCQ showed elevation in plasma Par-4 levels over basal levels. | Hydroxychloroquine | Prader Willi/Angelman region RNA 4 | Homo sapiens |
| 5 | The resected tumors from the eight HCQ-treated patients with elevated plasma Par-4 levels, but not the resected tumor from the patient who failed to induce plasma Par-4 levels, exhibited TUNEL-positivity indicative of apoptosis. | Hydroxychloroquine | Prader Willi/Angelman region RNA 4 | Homo sapiens |
| 6 | The resected tumors from the eight HCQ-treated patients with elevated plasma Par-4 levels, but not the resected tumor from the patient who failed to induce plasma Par-4 levels, exhibited TUNEL-positivity indicative of apoptosis. | Hydroxychloroquine | Prader Willi/Angelman region RNA 4 | Homo sapiens |