Title : New life for an old drug: In vitro and in vivo effects of the anthelmintic drug niclosamide against Toxoplasma gondii RH strain.

Pub. Date : 2019 Apr

PMID : 30599391






3 Functional Relationships(s)
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1 Niclosamide displayed low host toxicity and its 50% inhibitory concentration was 8.3 mug/mL. Niclosamide thrombopoietin Mus musculus
2 Niclosamide also inhibited T. gondii tachyzoite proliferation, with a 50% effective concentration of 45.3 ng/mL, and reduced the invasion of cells by tachyzoites (17.8% for the parasite control versus 1.9% for the niclosamide group treated with 100 ng/mL). Niclosamide thrombopoietin Mus musculus
3 Niclosamide also inhibited T. gondii tachyzoite proliferation, with a 50% effective concentration of 45.3 ng/mL, and reduced the invasion of cells by tachyzoites (17.8% for the parasite control versus 1.9% for the niclosamide group treated with 100 ng/mL). Niclosamide thrombopoietin Mus musculus