Title : Sitagliptin protects the cognition function of the Alzheimer's disease mice through activating glucagon-like peptide-1 and BDNF-TrkB signalings.

Pub. Date : 2019 Mar 23

PMID : 30597232






3 Functional Relationships(s)
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1 Sitagliptin protects the cognition function of the Alzheimer"s disease mice through activating glucagon-like peptide-1 and BDNF-TrkB signalings. Sitagliptin Phosphate glucagon Mus musculus
2 Furthermore, exendin-(9-39) (a glucagon-like peptide-1 [GLP-1] receptor antagonist) and K252a (a Trk tyrosine kinase inhibitor) treatment significantly abolished the cognitive protective effect of sitagliptin in the MWM test. Sitagliptin Phosphate glucagon Mus musculus
3 CONCLUSION: Sitagliptin treatment effectively protected the cognition function of the AD mice by regulating synaptic plasticity, at least partially, through activating GLP-1 and BDNF-TrkB signalings. Sitagliptin Phosphate glucagon Mus musculus