Pub. Date : 2019 Jan
PMID : 30593388
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | MTX is irreversibly hydroxylated to form 7-hydroxy methotrexate (7-OH-MTX) by aldehyde oxidase (EC 1.2.3.1) (AOX). | 7-hydroxymethotrexate | acyl-CoA oxidase 1 | Homo sapiens |
| 2 | MTX is irreversibly hydroxylated to form 7-hydroxy methotrexate (7-OH-MTX) by aldehyde oxidase (EC 1.2.3.1) (AOX). | 7-hydroxymethotrexate | acyl-CoA oxidase 1 | Homo sapiens |
| 3 | Our hypothesis is that in postmenopausal women with RA and osteoporosis treated with MTX and raloxifene, the inhibition of AOX with resultant decreased formation of 7-OH MTX; will increase MTX levels and improve MTX efficacy. | 7-hydroxymethotrexate | acyl-CoA oxidase 1 | Homo sapiens |