Pub. Date : 2019 Feb
PMID : 30592172
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | RNA-seq and bioinformatics analysis showed that apoptosis, death receptor signaling pathway, TNF signaling pathway, and TP53 regulated transcription of cell death genes pathway were closely associated with paclitaxel in the treatment of GCTB. | Paclitaxel | tumor protein p53 | Homo sapiens |
| 2 | Western bolt results revealed that paclitaxel induced cleavage of Caspase-3 and PARP1, and increased the phosphorylation level of p53 in HS 737.T cells. | Paclitaxel | tumor protein p53 | Homo sapiens |
| 3 | CONCLUSION: Paclitaxel can significantly repress cell proliferation and induce apoptosis of HS 737.T cells through activating Caspase-3, PARP1, p53, and TP53INP1. | Paclitaxel | tumor protein p53 | Homo sapiens |