Pub. Date : 2018
PMID : 30588188
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | RIPK1 Inhibition Enhances Pirarubicin Cytotoxic Efficacy through AKT-P21-dependent Pathway in Hepatocellular Carcinoma. | pirarubicin | cyclin-dependent kinase inhibitor 1A (P21) | Mus musculus |
| 2 | Here we found that RIPK1 and p21 may participate in the resistance to pirarubicin. | pirarubicin | cyclin-dependent kinase inhibitor 1A (P21) | Mus musculus |
| 3 | Moreover, phosphorylation of AKT reversed the anti-proliferative effect of RIPK1 inhibitor in HCC, which proved that RIPK1-AKT-P21-dependent pathway played a key role in pirarubicin resistance. | pirarubicin | cyclin-dependent kinase inhibitor 1A (P21) | Mus musculus |
| 4 | Upon exposure to pirarubicin treatment, xenografts under RIPK1 inhibition maintained higher levels of p21 than control xenografts. | pirarubicin | cyclin-dependent kinase inhibitor 1A (P21) | Mus musculus |