Title : SIRT1 alleviates isoniazid-induced hepatocyte injury by reducing histone acetylation in the IL-6 promoter region.

Pub. Date : 2019 Feb

PMID : 30578970






1 Functional Relationships(s)
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1 We found that compared with the blank control group, expression of SIRT1 was decreased in the isoniazid group and that expression of NF-kappaB p65 was increased, leading to an increase of the expression of inflammatory cytokines Interleukin-6 (IL-6) and Tumour necrosis factor alpha (TNF-alpha). Isoniazid tumor necrosis factor Homo sapiens