Title : Extra-mitochondrial Cu/Zn superoxide dismutase (Sod1) is dispensable for protection against oxidative stress but mediates peroxide signaling in Saccharomyces cerevisiae.

Pub. Date : 2019 Feb

PMID : 30576923






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Cu/Zn Superoxide Dismutase (Sod1) is a highly conserved and abundant metalloenzyme that catalyzes the disproportionation of superoxide radicals into hydrogen peroxide and molecular oxygen. Superoxides superoxide dismutase SOD1 Saccharomyces cerevisiae S288C
2 As a consequence, Sod1 serves dual roles in oxidative stress protection and redox signaling by both scavenging cytotoxic superoxide radicals and producing hydrogen peroxide that can be used to oxidize and regulate the activity of downstream targets. Superoxides superoxide dismutase SOD1 Saccharomyces cerevisiae S288C
3 Using the model unicellular eukaryote, Baker"s yeast, we found that only a small fraction of the total Sod1 pool is required for protection against superoxide toxicity and that this pool is localized to the mitochondrial intermembrane space. Superoxides superoxide dismutase SOD1 Saccharomyces cerevisiae S288C