Pub. Date : 2019 Mar
PMID : 30569112
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Early decrease in serum amphiregulin or vascular endothelial growth factor levels predicts sorafenib efficacy in hepatocellular carcinoma. | Sorafenib | vascular endothelial growth factor A | Homo sapiens |
| 2 | The aim of the present study was to investigate the effect of sorafenib on two growth factors implicated in autocrine loops and HCC tumour invasion: amphiregulin (AREG) and vascular endothelial growth factor (VEGF). | Sorafenib | vascular endothelial growth factor A | Homo sapiens |
| 3 | The aim of the present study was to investigate the effect of sorafenib on two growth factors implicated in autocrine loops and HCC tumour invasion: amphiregulin (AREG) and vascular endothelial growth factor (VEGF). | Sorafenib | vascular endothelial growth factor A | Homo sapiens |
| 4 | It was observed that sorafenib decreased AREG, VEGF and cytokine expression at the transcriptional and post-transcriptional levels. | Sorafenib | vascular endothelial growth factor A | Homo sapiens |
| 5 | The decreased serum levels of AREG and VEGF after 15 days of sorafenib treatment were significantly associated with better overall and progression-free survival. | Sorafenib | vascular endothelial growth factor A | Homo sapiens |
| 6 | These results suggest that sorafenib inhibits auto-crine loops and that early decrease in serum AREG or VEGF levels predicts sorafenib efficacy in HCC patients. | Sorafenib | vascular endothelial growth factor A | Homo sapiens |