Title : Possible Influences of Endogenous and Exogenous Ligands on the Evolution of Human Siglecs.

Pub. Date : 2018

PMID : 30564250






1 Functional Relationships(s)
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1 A type of sialic acid called N-glycolylneuraminic acid (Neu5Gc) is abundant in many mammalian lineages including great apes, the closest extant relatives of modern human, but was lost in the lineage leading to modern human via the pseudogenization of the CMAH gene encoding the enzyme that converts N-acetylneuraminic acid (Neu5Ac) to Neu5Gc. N-Acetylneuraminic Acid cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene Homo sapiens