Pub. Date : 2018 Dec 15
PMID : 30558329
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Epigallocatechin-3 Gallate Inhibits STAT-1/JAK2/IRF-1/HLA-DR/HLA-B and Reduces CD8 MKG2D Lymphocytes of Alopecia Areata Patients. | epigallocatechin gallate | signal transducer and activator of transcription 1 | Homo sapiens |
| 2 | In vitro treatment of HaCat and Jurkat cells with 40 mum EGCG for 48 h was performed to measure the level of phosphorylation of signal transducer and activator of transcription protein STAT1, and replicated in ex vivo model using PBMCs of AA patients. | epigallocatechin gallate | signal transducer and activator of transcription 1 | Homo sapiens |
| 3 | RESULTS: Interestingly, 40 mum EGCG is capable of completely inhibiting phosphorylation of STAT1 after 48 h in HaCat and Jurkat cells and ex vivo in PBMCs of AA patients. | epigallocatechin gallate | signal transducer and activator of transcription 1 | Homo sapiens |
| 4 | Based on QPCR data, the action of EGCG on p-STAT1 seems to be mediated via downregulation of the expression of JAK2 but not JAK1 leading to the inhibition of human leukocyte antigens (HLA-DR and HLA-B) expression probably via IRF-1. | epigallocatechin gallate | signal transducer and activator of transcription 1 | Homo sapiens |