Title : Critical role of Cav3.2 T-type calcium channels in the peripheral neuropathy induced by bortezomib, a proteasome-inhibiting chemotherapeutic agent, in mice.

Pub. Date : 2019 Feb 1

PMID : 30552955






2 Functional Relationships(s)
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1 Protein levels of USP5, a deubiquitinating enzyme that specifically inhibits proteasomal degradation of Cav3.2, increased in DRG on days 3-21, but not day 1, in bortezomib-treated mice. Bortezomib ubiquitin specific peptidase 5 (isopeptidase T) Mus musculus
2 In DRG-derived ND7/23 cells, bortezomib increased protein levels of Cav3.2 and T-channel-dependent currents, as assessed by a patch-clamp method, but did not upregulate expression of Cav3.2 mRNA or USP5 protein. Bortezomib ubiquitin specific peptidase 5 (isopeptidase T) Mus musculus