Title : Blockade of nicotinic acetylcholine receptor enhances the responsiveness to bupropion in the mouse forced swim test.

Pub. Date : 2019 Mar 15

PMID : 30552947






2 Functional Relationships(s)
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1 The objective of the present study is to investigate the role of alpha4, alpha5, alpha6 or beta2 nAChR subunits in the antidepressant-like effect of bupropion. Bupropion immunoglobulin (CD79A) binding protein 1 Mus musculus
2 Bupropion significantly decreased immobility time and increased climbing time in the alpha4, alpha6 and beta2 nAChR KO mice in comparison to WT littermates, indicating that lack of these nAChR subunits enhanced antidepressant effects of bupropion. Bupropion immunoglobulin (CD79A) binding protein 1 Mus musculus