Title : Sirtuin 4 Depletion Promotes Hepatocellular Carcinoma Tumorigenesis Through Regulating Adenosine-Monophosphate-Activated Protein Kinase Alpha/Mammalian Target of Rapamycin Axis in Mice.

Pub. Date : 2019 Apr

PMID : 30552782






1 Functional Relationships(s)
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1 Suppression of LKB1 or promotion of AMP by metformin also abrogated the hyperproliferative phenotype caused by SIRT4 loss, which further confirmed that the LKB1/AMPKalpha/mTOR axis is required in SIRT4-deficiency-promoted HCC tumorigenesis. Adenosine Monophosphate serine/threonine kinase 11 Homo sapiens