Pub. Date : 2019 Jan 15
PMID : 30551901
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here, we asked a specific SAR question unresolved in previous SAR studies of Niclosamide"s inhibition of Wnt/beta-catenin signaling to identify a new structural class of Wnt/beta-catenin signaling inhibitors based on a triazole motif. | Niclosamide | sarcosine dehydrogenase | Homo sapiens |
| 2 | Here, we asked a specific SAR question unresolved in previous SAR studies of Niclosamide"s inhibition of Wnt/beta-catenin signaling to identify a new structural class of Wnt/beta-catenin signaling inhibitors based on a triazole motif. | Niclosamide | sarcosine dehydrogenase | Homo sapiens |
| 3 | Overall, these studies demonstrate the ability to use the SAR of the Niclosamide salicylanilide chemical class to expand the structural diversity of Wnt/beta-catenin inhibitors. | Niclosamide | sarcosine dehydrogenase | Homo sapiens |