Pub. Date : 2019 Jan
PMID : 30551489
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Icariin ameliorates cisplatin-induced cytotoxicity in human embryonic kidney 293 cells by suppressing ROS-mediated PI3K/Akt pathway. | icariin | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Importantly, LY294002, a specific PI3K inhibitor, abrogated the anti-apoptosis effect of icariin, implicating the involvement of PI3K/Akt pathway. | icariin | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | In summary, icariin prevents cisplatin-induced HEK-293 cell injury by inhibiting oxidative stress, inflammatory response, and cellular apoptosis partly via regulating NF-kappaB and PI3K/Akt signaling pathways. | icariin | AKT serine/threonine kinase 1 | Homo sapiens |