Title : Lack of urea transporters, UT-A1 and UT-A3, increases nitric oxide accumulation to dampen medullary sodium reabsorption through ENaC.

Pub. Date : 2019 Mar 1

PMID : 30539654






1 Functional Relationships(s)
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1 WT, UT-A3 KO, and UT-A1/A3 KO acutely respond to hydrochlorothiazide and furosemide; however, UT-A1/A3 KO fail to show a diuretic or natriuretic response following amiloride administration, indicating that baseline epithelial Na+ channel (ENaC) activity is impaired. Hydrochlorothiazide solute carrier family 14 (urea transporter), member 2 Mus musculus