Title : Engineered Thymidine-Active Deoxycytidine Kinase for Bystander Killing of Malignant Cells.

Pub. Date : 2019

PMID : 30539536






2 Functional Relationships(s)
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1 We have developed a novel SGTC system based on viral vector-mediated delivery of an engineered variant of human deoxycytidine kinase (dCK), which is capable of phosphorylating uridine- and thymidine-based nucleoside analogues that are not substrates for wild-type dCK, such as bromovinyl deoxyuridine (BVdU) and L-deoxythymidine (LdT). Nucleosides Calcium/calmodulin-dependent protein kinase II Drosophila melanogaster
2 We have developed a novel SGTC system based on viral vector-mediated delivery of an engineered variant of human deoxycytidine kinase (dCK), which is capable of phosphorylating uridine- and thymidine-based nucleoside analogues that are not substrates for wild-type dCK, such as bromovinyl deoxyuridine (BVdU) and L-deoxythymidine (LdT). Nucleosides Calcium/calmodulin-dependent protein kinase II Drosophila melanogaster