Title : Identification and Characterization of Synthetic Viability with ERCC1 Deficiency in Response to Interstrand Crosslinks in Lung Cancer.

Pub. Date : 2019 Apr 15

PMID : 30538112






1 Functional Relationships(s)
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1 RESULTS: We observe that loss of ERCC1 hypersensitizes cells to cisplatin when wild-type (WT) p53 is retained, whereas there is only modest sensitivity in cell lines that are p53mutant/null. Cisplatin ERCC excision repair 1, endonuclease non-catalytic subunit Homo sapiens