Pub. Date : 2019 Apr 15
PMID : 30538112
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In addition, when p53 is disrupted by CRISPR-Cas9 (p53*) in ERCC1Delta/p53WT cells, there is reduced apoptosis and increased viability after platinum treatment. | Platinum | tumor protein p53 | Homo sapiens |
| 2 | In addition, when p53 is disrupted by CRISPR-Cas9 (p53*) in ERCC1Delta/p53WT cells, there is reduced apoptosis and increased viability after platinum treatment. | Platinum | tumor protein p53 | Homo sapiens |
| 3 | CONCLUSIONS: Our findings implicate p53 as a potential confounding variable in clinical assessments of ERCC1 as a platinum biomarker via promoting an environment in which error-prone mechanisms of ICL-R may be able to partially compensate for loss of ERCC1.See related commentary by Friboulet et al., p. 2369. | Platinum | tumor protein p53 | Homo sapiens |