Pub. Date : 2018 Dec 10
PMID : 30526541
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Activation of LXRalpha/beta by cholesterol in malignant ascites promotes chemoresistance in ovarian cancer. | Cholesterol | nuclear receptor subfamily 1 group H member 3 | Homo sapiens |
| 2 | RESULTS: Here we show that cholesterol is elevated in malignant ascites and modulates the sensitivity of ovarian cancer cells to CDDP and PAC by upregulating the expression of drug efflux pump proteins, ABCG2 and MDR1, together with upregulation of LXRalpha/beta, the cholesterol receptor. | Cholesterol | nuclear receptor subfamily 1 group H member 3 | Homo sapiens |
| 3 | Transfection of LXRalpha/beta siRNA inhibited cholesterol-induced chemoresistance and upregulation of MDR1. | Cholesterol | nuclear receptor subfamily 1 group H member 3 | Homo sapiens |
| 4 | Cholesterol depletion by methyl beta cyclodextrin (MbetaCD) inhibited malignant ascites-induced chemoresistance to CDDP and upregulation of MDR1 and LXRalpha/beta. | Cholesterol | nuclear receptor subfamily 1 group H member 3 | Homo sapiens |
| 5 | CONCLUSIONS: High cholesterol in malignant ascites contributes to poor prognosis in ovarian cancer patients, partly by contributing to multidrug resistance through upregulation of MDR1 via activation of LXRalpha/beta. | Cholesterol | nuclear receptor subfamily 1 group H member 3 | Homo sapiens |