Title : Long noncoding RNA H19 mediated the chemosensitivity of breast cancer cells via Wnt pathway and EMT process.

Pub. Date : 2018

PMID : 30519041






6 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Results: We found that lncRNA H19 expression level manipulated breast cancer cell proliferation both in parental breast cancer cell lines and tamoxifen-resistant cell lines. Tamoxifen H19 imprinted maternally expressed transcript Homo sapiens
2 Knockdown of lncRNA H19 elevated tamoxifen sensitivity for promoting cell growth and inhibiting apoptosis in tamoxifen-resistant breast cancer cells. Tamoxifen H19 imprinted maternally expressed transcript Homo sapiens
3 Knockdown of lncRNA H19 elevated tamoxifen sensitivity for promoting cell growth and inhibiting apoptosis in tamoxifen-resistant breast cancer cells. Tamoxifen H19 imprinted maternally expressed transcript Homo sapiens
4 Moreover, knockdown of H19 inhibited Wnt pathway and epithelia-mesenchymal transition in tamoxifen-resistance breast cancer cells. Tamoxifen H19 imprinted maternally expressed transcript Homo sapiens
5 Conclusion: Taken together, the results of this study provided the evidence for H19 in regulating tamoxifen-resistant breast cancer and might provide novel options in the future treatment of tamoxifen-resistance breast cancer patients. Tamoxifen H19 imprinted maternally expressed transcript Homo sapiens
6 Conclusion: Taken together, the results of this study provided the evidence for H19 in regulating tamoxifen-resistant breast cancer and might provide novel options in the future treatment of tamoxifen-resistance breast cancer patients. Tamoxifen H19 imprinted maternally expressed transcript Homo sapiens