Pub. Date : 2018 Dec
PMID : 30501711
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | OBJECTIVE: To study the effects of iron metabolism abnormality on EPO-STAT5 signaling pathway in anemia patients. | Iron | erythropoietin | Homo sapiens |
| 2 | Moreover, the effects of iron metabolism abnormality on the expression of EPO and STAT5 in anemia patients were analyzed. | Iron | erythropoietin | Homo sapiens |
| 3 | RESULTS: compared with non-iron over load group, the EPO level in iron over load group significantly increased (P<0.05), the expression of STAT5 mRNA and P-STAT5 significantly decreased (P<0.05). | Iron | erythropoietin | Homo sapiens |
| 4 | RESULTS: compared with non-iron over load group, the EPO level in iron over load group significantly increased (P<0.05), the expression of STAT5 mRNA and P-STAT5 significantly decreased (P<0.05). | Iron | erythropoietin | Homo sapiens |
| 5 | After iron chelation therapy, the EPO level in serum significantly decreased (P<0.05), the expression of STAT5 mRNA and P-STAT5 was up-regulated significantly (P<0.05). | Iron | erythropoietin | Homo sapiens |
| 6 | CONCLUSION: The excessive iron load or chronic inflammation may inhibit the activation of EPO-STAT5 signaling pathway and aggravate the anemia. | Iron | erythropoietin | Homo sapiens |