Title : Tylophorine Abrogates G2/M Arrest Induced by Doxorubicine and Promotes Increased Apoptosis in T47D Breast Cancer Cells

Pub. Date : 2018 Nov 29

PMID : 30485942






3 Functional Relationships(s)
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1 Expression of proapoptoticproteins (caspases 3 and 9) was up-regulated upon administration of tyloporine alone or in combination with doxorubicin.Conclusions: Tylophorine alone or in combination with doxorubicin induced apoptosis in T47D breast cancer cellsthrough modulation of the cell cycle and affecting the expression of caspases 3 and 9. Doxorubicin caspase 3 Homo sapiens
2 Expression of proapoptoticproteins (caspases 3 and 9) was up-regulated upon administration of tyloporine alone or in combination with doxorubicin.Conclusions: Tylophorine alone or in combination with doxorubicin induced apoptosis in T47D breast cancer cellsthrough modulation of the cell cycle and affecting the expression of caspases 3 and 9. Doxorubicin caspase 3 Homo sapiens
3 Expression of proapoptoticproteins (caspases 3 and 9) was up-regulated upon administration of tyloporine alone or in combination with doxorubicin.Conclusions: Tylophorine alone or in combination with doxorubicin induced apoptosis in T47D breast cancer cellsthrough modulation of the cell cycle and affecting the expression of caspases 3 and 9. Doxorubicin caspase 3 Homo sapiens