Title : Identification of Pyrrolidine-3-acetic Acid Derived Oximes as Potent Inhibitors of γ-Aminobutyric Acid Transporter 1 through Library Screening with MS Binding Assays.

Pub. Date : 2018 Dec 6

PMID : 30485691






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In this study, pyrrolidine-3-acetic acid derived oxime libraries were applied to the concept of library screening by MS Binding Assays, as a powerful technique to reveal new potent murine gamma-aminobutyric acid transporter subtype (mGAT1) inhibitors. Oximes solute carrier family 6 (neurotransmitter transporter, GABA), member 1 Mus musculus
2 The oxime libraries have been screened by means of competitive MS Binding Assays and, as a consequence, the most active libraries were further investigated through deconvolution experiments to identify single oximes responsible for the observed activity on the target mGAT1. Oximes solute carrier family 6 (neurotransmitter transporter, GABA), member 1 Mus musculus
3 The oxime libraries have been screened by means of competitive MS Binding Assays and, as a consequence, the most active libraries were further investigated through deconvolution experiments to identify single oximes responsible for the observed activity on the target mGAT1. Oximes solute carrier family 6 (neurotransmitter transporter, GABA), member 1 Mus musculus