Pub. Date : 2019 Feb
PMID : 30483799
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Erythropoietin promotes expression of survivin via STAT3 activation and reduces sensitivity to cisplatin in cervical cancer cells. | Cisplatin | erythropoietin | Homo sapiens |
| 2 | However, certain studies have identified that the administration of Epo mediates the acquisition of resistance to cisplatin, which is widely used to treat cervical cancer. | Cisplatin | erythropoietin | Homo sapiens |
| 3 | Thus, the aim of the present study was to assess the potential effect of Epo on the cytotoxic activity of cisplatin in cervical cancer cells. | Cisplatin | erythropoietin | Homo sapiens |
| 4 | It was observed that pre-incubation with Epo induced a significant reduction of cisplatin-induced apoptosis in vitro and in vivo. | Cisplatin | erythropoietin | Homo sapiens |
| 5 | These observations indicated that Epo was able to hinder the cytotoxic effect of cisplatin in cervical cancer cells by activating anti-apoptotic responses regulated by STAT3. | Cisplatin | erythropoietin | Homo sapiens |