Title : In vivo phenotyping of cytochrome 450 isoforms involved in the metabolism of anti-HIV and anti-tubercular drugs in human using cocktail approach: An LC-MS/MS analysis.

Pub. Date : 2019 Feb 5

PMID : 30472588






2 Functional Relationships(s)
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1 In this study, we used a cocktail of bupropion, losartan and dapsone for in vivo phenotyping of CYP2B6, CYP2C9 and N-acetyltransferase-2 (NAT2) in plasma. Bupropion cytochrome P450 family 2 subfamily B member 6 Homo sapiens
2 CONCLUSIONS: This study advocates the use of a cocktail of bupropion, losartan and dapsone for in vivo phenotyping of CYP2B6, CYP2C9 and NAT2, which is important in determining therapeutic dose levels of anti-HIV and anti-TB drugs in HIV/AIDS-TB coinfections. Bupropion cytochrome P450 family 2 subfamily B member 6 Homo sapiens