Pub. Date : 2019 Jan 1
PMID : 30472297
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Tilianin mediates neuroprotection against ischemic injury by attenuating CaMKII-dependent mitochondrion-mediated apoptosis and MAPK/NF-kappaB signaling. | tilianin | calcium/calmodulin dependent protein kinase II gamma | Homo sapiens |
| 2 | Of these intersectional cascades, Ca2+/calmodulin-dependent protein kinase II (CaMKII) was found to bind efficiently with tilianin. | tilianin | calcium/calmodulin dependent protein kinase II gamma | Homo sapiens |
| 3 | Of these intersectional cascades, Ca2+/calmodulin-dependent protein kinase II (CaMKII) was found to bind efficiently with tilianin. | tilianin | calcium/calmodulin dependent protein kinase II gamma | Homo sapiens |
| 4 | Importantly, after utilizing KN93, one specific CaMKII inhibitor, tilianin-mediated neuroprotection against OGD was abolished. | tilianin | calcium/calmodulin dependent protein kinase II gamma | Homo sapiens |
| 5 | Thus, the beneficial effects of tilianin toward mitochondrion-mediated apoptosis and p38/JNK/NF-kappaB-associated inflammatory pathways were reversed following CaMKII inhibition. | tilianin | calcium/calmodulin dependent protein kinase II gamma | Homo sapiens |
| 6 | SIGNIFICANCE: Our study indicated that attenuation of CaMKII-linked signaling mediated through mitochondria and p38/JNK/NF-kappaB inflammatory pathways is a key mechanism by which tilianin exerts its neuroprotective effects against cerebral ischemia. | tilianin | calcium/calmodulin dependent protein kinase II gamma | Homo sapiens |