Pub. Date : 2019 Feb 1
PMID : 30472223
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Pifithrin-alpha enhancing anticancer effect of topotecan on p53-expressing cancer cells. | pifithrin | tumor protein p53 | Homo sapiens |
| 2 | In this study, pifithrin-alpha (PFTalpha), a p53 inhibitor, was used 2 h before treated with TPT on three kinds of cancer cell lines including MCF7, BGC823 and HepG2 cells. | pifithrin | tumor protein p53 | Homo sapiens |
| 3 | In this study, pifithrin-alpha (PFTalpha), a p53 inhibitor, was used 2 h before treated with TPT on three kinds of cancer cell lines including MCF7, BGC823 and HepG2 cells. | pifithrin | tumor protein p53 | Homo sapiens |
| 4 | It was demonstrated that PFTalpha decreases the p-p53 levels and p-p53 activity, not affects p53 expression in p53 positive tumor cells. | pifithrin | tumor protein p53 | Homo sapiens |
| 5 | It was demonstrated that PFTalpha decreases the p-p53 levels and p-p53 activity, not affects p53 expression in p53 positive tumor cells. | pifithrin | tumor protein p53 | Homo sapiens |
| 6 | It was demonstrated that PFTalpha decreases the p-p53 levels and p-p53 activity, not affects p53 expression in p53 positive tumor cells. | pifithrin | tumor protein p53 | Homo sapiens |
| 7 | It was demonstrated that PFTalpha decreases the p-p53 levels and p-p53 activity, not affects p53 expression in p53 positive tumor cells. | pifithrin | tumor protein p53 | Homo sapiens |
| 8 | Secondly, PFTalpha decreased formation of p53/mdm2 complex responsible for p53 degradation by inhibiting the protein expression of mdm2, so p53 degradation was decreased in cytoplasm and p53 accumulation was increased in nucleus, which induced more cells undergo apoptosis. | pifithrin | tumor protein p53 | Homo sapiens |
| 9 | Secondly, PFTalpha decreased formation of p53/mdm2 complex responsible for p53 degradation by inhibiting the protein expression of mdm2, so p53 degradation was decreased in cytoplasm and p53 accumulation was increased in nucleus, which induced more cells undergo apoptosis. | pifithrin | tumor protein p53 | Homo sapiens |
| 10 | Secondly, PFTalpha decreased formation of p53/mdm2 complex responsible for p53 degradation by inhibiting the protein expression of mdm2, so p53 degradation was decreased in cytoplasm and p53 accumulation was increased in nucleus, which induced more cells undergo apoptosis. | pifithrin | tumor protein p53 | Homo sapiens |
| 11 | Secondly, PFTalpha decreased formation of p53/mdm2 complex responsible for p53 degradation by inhibiting the protein expression of mdm2, so p53 degradation was decreased in cytoplasm and p53 accumulation was increased in nucleus, which induced more cells undergo apoptosis. | pifithrin | tumor protein p53 | Homo sapiens |