Title : Quercetin inhibits Mrgprx2-induced pseudo-allergic reaction via PLCĪ³-IP3R related Ca2+ fluctuations.

Pub. Date : 2019 Jan

PMID : 30471617






1 Functional Relationships(s)
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1 In Mrgprx2 knockdown LAD2 cells, the effect of Quercetin (200 muM) reduced C48/80 induced calcium flux and the release of beta-hexosaminidase, histamine, MCP-1 and IL-8 compared with non-atopic control (NC) transfected LAD2 human mast cells, suggesting that Quercetin anti-pseudo-allergic effect was related to Mrgprx2. Quercetin C-X-C motif chemokine ligand 8 Homo sapiens