Title : Vitamin E δ-tocotrienol inhibits TNF-α-stimulated NF-κB activation by up-regulation of anti-inflammatory A20 via modulation of sphingolipid including elevation of intracellular dihydroceramides.

Pub. Date : 2019 Feb

PMID : 30471562






6 Functional Relationships(s)
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1 Vitamin E delta-tocotrienol inhibits TNF-alpha-stimulated NF-kappaB activation by up-regulation of anti-inflammatory A20 via modulation of sphingolipid including elevation of intracellular dihydroceramides. tocotrienol, delta TNF alpha induced protein 3 Homo sapiens
2 In pursuit of the cause for A20 induction, we found that deltaTE treatment caused rapid and persistent elevation of dihydroceramides, while decreased ceramides initially but increased ceramides during prolonged treatment. tocotrienol, delta TNF alpha induced protein 3 Homo sapiens
3 Importantly, deltaTE"s induction of A20 and inhibition of NF-kappaB activation were partially counteracted by myriocin, a potent inhibitor of de novo synthesis of sphingolipids, indicating a critical role of sphingolipid modulation in deltaTE-mediated effects. tocotrienol, delta TNF alpha induced protein 3 Homo sapiens
4 Importantly, deltaTE"s induction of A20 and inhibition of NF-kappaB activation were partially counteracted by myriocin, a potent inhibitor of de novo synthesis of sphingolipids, indicating a critical role of sphingolipid modulation in deltaTE-mediated effects. tocotrienol, delta TNF alpha induced protein 3 Homo sapiens
5 Since dihydroceramide has been shown to induce A20 and inhibit NF-kappaB in RAW cells, we conclude that that deltaTE inhibits NF-kappaB activation by enhancing its negative regulator A20 as a result of modulating sphingolipids especially elevation of dihydroceramides. tocotrienol, delta TNF alpha induced protein 3 Homo sapiens
6 Since dihydroceramide has been shown to induce A20 and inhibit NF-kappaB in RAW cells, we conclude that that deltaTE inhibits NF-kappaB activation by enhancing its negative regulator A20 as a result of modulating sphingolipids especially elevation of dihydroceramides. tocotrienol, delta TNF alpha induced protein 3 Homo sapiens