Title : Evaluation of hepatic function using dynamic contrast-enhanced magnetic resonance imaging in melanocortin 4 receptor-deficient mice as a model of nonalcoholic steatohepatitis.

Pub. Date : 2019 Apr

PMID : 30465867






2 Functional Relationships(s)
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1 DCE-MRI with Gd-EOB-DTPA showed that Tmax and T1/2 were significantly longer in MC4R-KO mice fed an HFD compared with wild type (WT) mice (Tmax, WT, 3.9 +- 0.4 min; MC4R-KO, 7.4 +- 1.5 min; T1/2, WT, 23.7 +- 1.9 min; MC4R-KO, 62.5 +- 18.5 min). gadolinium ethoxybenzyl DTPA melanocortin 4 receptor Mus musculus
2 The liver kinetics of Gd-EOB-DTPA were significantly different in MC4R-KO mice fed an HFD from WT mice, and correlated with the histopathologic score. gadolinium ethoxybenzyl DTPA melanocortin 4 receptor Mus musculus