Pub. Date : 2018 Dec 9
PMID : 30458987
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Exosomal transfer of miR-214 mediates gefitinib resistance in non-small cell lung cancer. | Gefitinib | microRNA 214 | Homo sapiens |
| 2 | MiRNA-214 was upregulated in gefitinib resistant PC-9GR cells and its derived exosomes by qPCR analysis. | Gefitinib | microRNA 214 | Homo sapiens |
| 3 | Inhibition of exosomal miR-214 with antagomir reversed gefitinib resistance conferred by PC-9GR-derived exosomes in vitro, which was confirmed by flow cytometry analysis and westernblot of apoptotic protein (caspase-3, caspase-3 cleaved, bax) and anti-apoptotic protein (bcl-2). | Gefitinib | microRNA 214 | Homo sapiens |
| 4 | Finally, exosomes enriched with miR-214 antagomir was further confirmed to reverse gefitinib resistance in vivo. | Gefitinib | microRNA 214 | Homo sapiens |
| 5 | Our results are the first to show that exosomes derived from gefitinib-resistant PC-9GR cells could transfer resistance to its recipient sensitive PC-9 cells, which might be mediated by exosomal transfer of miR-214. | Gefitinib | microRNA 214 | Homo sapiens |