Title : The novel PI3K inhibitor S1 synergizes with sorafenib in non-small cell lung cancer cells involving the Akt-S6 signaling.

Pub. Date : 2019 Oct

PMID : 30456603






1 Functional Relationships(s)
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1 The combination of S1 and sorafenib exerts potentiated anti-tumor effects, in which the underlying mechanisms may involve their differential modulation of the phosphorylation of Akt and S6 in the PI3K/Akt/mTOR cascades and ERK phosphorylation in the Raf/MEK/ERK pathways. Sorafenib zinc fingers and homeoboxes 2 Homo sapiens