Title : Stable transgenic C9orf72 zebrafish model key aspects of the ALS/FTD phenotype and reveal novel pathological features.

Pub. Date : 2018 Nov 19

PMID : 30454072






1 Functional Relationships(s)
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1 Lastly, we identified that the compound ivermectin, as well as riluzole, reduced HSR activation in both C9-ALS/FTD and SOD1 zebrafish models.Thus, our C9-ALS/FTD zebrafish model is a stable transgenic model which recapitulates key features of human C9orf72-ALS/FTD, and represents a powerful drug-discovery tool. Ivermectin C9orf72-SMCR8 complex subunit Homo sapiens