Title : JNK and ATF4 as two important platforms for tumor necrosis factor-α-stimulated shedding of receptor for advanced glycation end products.

Pub. Date : 2019 Mar

PMID : 30452882






1 Functional Relationships(s)
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1 Although the endoplasmic reticulum stressors thapsigargin and tunicamycin induced markedly and sustained expression of ATF4 and XBP-1, they did not induce RAGE shedding to the same level as TNF-alpha, suggesting that ATF4 is necessary but not sufficient alone for TNF-alpha-mediated RAGE shedding. Tunicamycin X-box binding protein 1 Homo sapiens