Title : Accumulation of PtdIns(4)P at the Golgi mediated by reversible oxidation of the PtdIns(4)P phosphatase Sac1 by H2O2.

Pub. Date : 2019 Jan

PMID : 30448513






1 Functional Relationships(s)
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1 Here we show that Sac1undergoes reversible inactivation in mammalian cells when its catalytic Cys389 residue is oxidized by exogenous H2O2 to form an intramolecular disulfide with Cys392. Disulfides SAC1 like phosphatidylinositide phosphatase Homo sapiens