Pub. Date : 2019 Jan 15
PMID : 30445019
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Resveratrol protects cardiomyocytes against anoxia/reoxygenation via dephosphorylation of VDAC1 by Akt-GSK3 beta pathway. | Resveratrol | voltage dependent anion channel 1 | Homo sapiens |
| 2 | Our previous studies showed that the effect of resveratrol preventing mitochondrial permeability transition pore (mPTP) opening in myocardial ischemia/reperfusion injury was achieved by regulating voltage-dependent anion channel 1 (VDAC1). | Resveratrol | voltage dependent anion channel 1 | Homo sapiens |
| 3 | Our previous studies showed that the effect of resveratrol preventing mitochondrial permeability transition pore (mPTP) opening in myocardial ischemia/reperfusion injury was achieved by regulating voltage-dependent anion channel 1 (VDAC1). | Resveratrol | voltage dependent anion channel 1 | Homo sapiens |
| 4 | In present study, we investigated whether resveratrol modulates VDAC1 phosphorylation to achieve cardioprotection and explored the signaling pathways involved. | Resveratrol | voltage dependent anion channel 1 | Homo sapiens |
| 5 | Moreover, our data showed that pretreatment with resveratrol prior to A/R injury inhibited VDAC1 phosphorylation. | Resveratrol | voltage dependent anion channel 1 | Homo sapiens |
| 6 | Dephosphorylated VDAC1 using pretreated resveratrol promoted dissociation with Bax and binding to HK2, which subsequently protected cardiomyocytes against A/R injury. | Resveratrol | voltage dependent anion channel 1 | Homo sapiens |
| 7 | Akt inhibitor IV abrogated Akt-GSK3beta phosphorylation and thereby abolished the dephosphorylation activity of resveratrol on VDAC1. | Resveratrol | voltage dependent anion channel 1 | Homo sapiens |
| 8 | Taken together, our data indicated that A/R injury enhanced VDAC1 phosphorylation in cardiomyocytes, whereas pretreatment with resveratrol dephosphorylated VDAC1 through the Akt-GSK3beta pathway, thereby protecting cardiomyocytes against A/R injury. | Resveratrol | voltage dependent anion channel 1 | Homo sapiens |