Pub. Date : 2019 Jan 15
PMID : 30445019
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Resveratrol protects cardiomyocytes against anoxia/reoxygenation via dephosphorylation of VDAC1 by Akt-GSK3 beta pathway. | Resveratrol | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | In addition, Akt and its downstream glycogen synthase kinase 3 beta (GSK3beta) were phosphorylated by the action of resveratrol. | Resveratrol | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Akt inhibitor IV abrogated Akt-GSK3beta phosphorylation and thereby abolished the dephosphorylation activity of resveratrol on VDAC1. | Resveratrol | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | Akt inhibitor IV abrogated Akt-GSK3beta phosphorylation and thereby abolished the dephosphorylation activity of resveratrol on VDAC1. | Resveratrol | AKT serine/threonine kinase 1 | Homo sapiens |
| 5 | Moreover, all resveratrol-mediated protective effects on A/R injured cardiomyocytes were abolished by Akt inhibitor IV. | Resveratrol | AKT serine/threonine kinase 1 | Homo sapiens |
| 6 | Taken together, our data indicated that A/R injury enhanced VDAC1 phosphorylation in cardiomyocytes, whereas pretreatment with resveratrol dephosphorylated VDAC1 through the Akt-GSK3beta pathway, thereby protecting cardiomyocytes against A/R injury. | Resveratrol | AKT serine/threonine kinase 1 | Homo sapiens |