Pub. Date : 2019 Feb
PMID : 30431068
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Investigating the mechanism, it was revealed that necroptosis may be induced in HCT116 p53+/+ cells by significantly increasing reactive oxygen species (ROS) and decreasing mitochondrial membrane potential (MMP), whereas little alterations were detected in HCT116 p53-/- cells. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 2 | Investigating the mechanism, it was revealed that necroptosis may be induced in HCT116 p53+/+ cells by significantly increasing reactive oxygen species (ROS) and decreasing mitochondrial membrane potential (MMP), whereas little alterations were detected in HCT116 p53-/- cells. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 3 | Furthermore, western blot analysis and ROS measurements indicated that AMPK inhibition, using dorsomorphin dihydrochloride, accelerated necroptosis by increasing ROS generation in HCT116 p53-/- cells. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |