Title : Sulforaphane metabolites reduce resistance to paclitaxel via microtubule disruption.

Pub. Date : 2018 Nov 14

PMID : 30429459






1 Functional Relationships(s)
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1 Here we uncovered that either sulforaphane-cysteine (SFN-Cys) or sulforaphane-N-acetyl-cysteine (SFN-NAC) induced apoptosis via phosphorylated ERK1/2-mediated upregulation of 26 S proteasome and Hsp70, and downregulation of betaIII-tubulin, XIAP, Tau, Stathmin1 and alpha-tubulin causing microtubule disruption in human PTX-resistant non-small cell lung cancer (NSCLC) cells. Sulforaphane-cysteine heat shock protein family A (Hsp70) member 4 Homo sapiens