Pub. Date : 2019 Mar
PMID : 30426505
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Doxorubicin-induced cardiotoxicity involves IFNgamma-mediated metabolic reprogramming in cardiomyocytes. | Doxorubicin | interferon gamma | Mus musculus |
| 2 | However, it is still not clear how the key inflammatory mediator interferon-gamma (IFNgamma) plays a role in doxorubicin (DOX)-induced cardiomyopathy. | Doxorubicin | interferon gamma | Mus musculus |
| 3 | However, it is still not clear how the key inflammatory mediator interferon-gamma (IFNgamma) plays a role in doxorubicin (DOX)-induced cardiomyopathy. | Doxorubicin | interferon gamma | Mus musculus |
| 4 | However, it is still not clear how the key inflammatory mediator interferon-gamma (IFNgamma) plays a role in doxorubicin (DOX)-induced cardiomyopathy. | Doxorubicin | interferon gamma | Mus musculus |
| 5 | However, it is still not clear how the key inflammatory mediator interferon-gamma (IFNgamma) plays a role in doxorubicin (DOX)-induced cardiomyopathy. | Doxorubicin | interferon gamma | Mus musculus |
| 6 | We report here that DOX-induced heart dysfunction involves IFNgamma signaling in mice. | Doxorubicin | interferon gamma | Mus musculus |
| 7 | In vitro, IFNgamma strongly aggravated the injury of cardiomyocytes exposed to DOX. | Doxorubicin | interferon gamma | Mus musculus |
| 8 | Although not affecting DOX-induced cell death, IFNgamma disrupted mitochondrial respiration and fatty acid oxidation in DOX-exposed cardiomyocytes. | Doxorubicin | interferon gamma | Mus musculus |
| 9 | IFNgamma extended the suppression of the AMP-activated protein kinase (AMPK)/acetyl-CoA carboxylase (ACC) axis by DOX to a p38-dependent branch. | Doxorubicin | interferon gamma | Mus musculus |
| 10 | Activation of AMPK or inhibition of p38 inhibited the enhancing effect of IFNgamma on the DOX-induced cardiotoxicity and prolonged the survival time in DOX-treated mice. | Doxorubicin | interferon gamma | Mus musculus |
| 11 | Activation of AMPK or inhibition of p38 inhibited the enhancing effect of IFNgamma on the DOX-induced cardiotoxicity and prolonged the survival time in DOX-treated mice. | Doxorubicin | interferon gamma | Mus musculus |
| 12 | Taken together, our results indicate that reprogramming of cardiac metabolism by IFNgamma represents a previously unidentified key step for DOX-induced cardiomyopathy. | Doxorubicin | interferon gamma | Mus musculus |