Title : Structure of human cortisol-producing cytochrome P450 11B1 bound to the breast cancer drug fadrozole provides insights for drug design.

Pub. Date : 2019 Jan 11

PMID : 30425102






2 Functional Relationships(s)
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1 Comparison of fadrozole-bound CYP11B1 with fadrozole-bound CYP11B2 revealed that despite conservation of the active-site residues, the overall structures and active sites had structural rearrangements consistent with distinct protein functions and inhibition. Fadrozole cytochrome P450 family 11 subfamily B member 2 Homo sapiens
2 Whereas fadrozole binds to both CYP11B enzymes by coordinating the heme iron, CYP11B2 binds to the R enantiomer of fadrozole, and CYP11B1 binds to the S enantiomer, each with distinct orientations and interactions. Fadrozole cytochrome P450 family 11 subfamily B member 2 Homo sapiens