Pub. Date : 2019 Jan 11
PMID : 30425102
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Structure of human cortisol-producing cytochrome P450 11B1 bound to the breast cancer drug fadrozole provides insights for drug design. | Fadrozole | cytochrome P450 family 11 subfamily B member 1 | Homo sapiens |
| 2 | Here we report the X-ray crystal structure of human CYP11B1 (at 2.1 A resolution) in complex with fadrozole, a racemic compound normally used to treat breast cancer by inhibiting estrogen-producing CYP19A1. | Fadrozole | cytochrome P450 family 11 subfamily B member 1 | Homo sapiens |
| 3 | Comparison of fadrozole-bound CYP11B1 with fadrozole-bound CYP11B2 revealed that despite conservation of the active-site residues, the overall structures and active sites had structural rearrangements consistent with distinct protein functions and inhibition. | Fadrozole | cytochrome P450 family 11 subfamily B member 1 | Homo sapiens |
| 4 | Whereas fadrozole binds to both CYP11B enzymes by coordinating the heme iron, CYP11B2 binds to the R enantiomer of fadrozole, and CYP11B1 binds to the S enantiomer, each with distinct orientations and interactions. | Fadrozole | cytochrome P450 family 11 subfamily B member 1 | Homo sapiens |