Title : Inhibiting APOBEC3 Activity with Single-Stranded DNA Containing 2'-Deoxyzebularine Analogues.

Pub. Date : 2019 Feb 5

PMID : 30418757






2 Functional Relationships(s)
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1 Here we show that, upon incorporation into short ssDNAs, the cytidine nucleoside analogue 2"-deoxyzebularine (dZ) becomes capable of inhibiting the catalytic activity of selected APOBEC variants derived from APOBEC3A, APOBEC3B, and APOBEC3G, supporting a mechanism in which ssDNA delivers dZ to the active site. 2'-deoxyzebularine apolipoprotein B mRNA editing enzyme catalytic subunit 3B Homo sapiens
2 Here we show that, upon incorporation into short ssDNAs, the cytidine nucleoside analogue 2"-deoxyzebularine (dZ) becomes capable of inhibiting the catalytic activity of selected APOBEC variants derived from APOBEC3A, APOBEC3B, and APOBEC3G, supporting a mechanism in which ssDNA delivers dZ to the active site. 2'-deoxyzebularine apolipoprotein B mRNA editing enzyme catalytic subunit 3B Homo sapiens