Pub. Date : 2019 Feb
PMID : 30414849
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | METHODS: TFEB activity was detected in NP tissues in puncture-induced rat IVDD model by immunofluorescence as well as in tert-Butyl hydroperoxide (TBHP), the reactive oxygen species (ROS) donor to induce oxidative stress, treated NP cells by western blot. | tert-Butylhydroperoxide | transcription factor EB | Rattus norvegicus |
| 2 | METHODS: TFEB activity was detected in NP tissues in puncture-induced rat IVDD model by immunofluorescence as well as in tert-Butyl hydroperoxide (TBHP), the reactive oxygen species (ROS) donor to induce oxidative stress, treated NP cells by western blot. | tert-Butylhydroperoxide | transcription factor EB | Rattus norvegicus |
| 3 | RESULTS: The nuclear localization of TFEB declined in degenerated rat NP tissue as well as in TBHP treated NP cells. | tert-Butylhydroperoxide | transcription factor EB | Rattus norvegicus |
| 4 | Applying lentivirus to transfect NP cells, TFEB overexpression restored the TBHP-induced autophagic flux blockage and protected NP cells against apoptosis and senescence; these protections of TFEB are diminished by chloroquine-medicated autophagy inhibition. | tert-Butylhydroperoxide | transcription factor EB | Rattus norvegicus |
| 5 | Applying lentivirus to transfect NP cells, TFEB overexpression restored the TBHP-induced autophagic flux blockage and protected NP cells against apoptosis and senescence; these protections of TFEB are diminished by chloroquine-medicated autophagy inhibition. | tert-Butylhydroperoxide | transcription factor EB | Rattus norvegicus |
| 6 | TFEB overexpression suppressed TBHP-induced apoptosis and senescence via autophagic flux stimulation in NP cell and alleviates puncture-induced IVDD development in vivo. | tert-Butylhydroperoxide | transcription factor EB | Rattus norvegicus |