Title : Opioid-mediated suppression of interferon-gamma production by cultured peripheral blood mononuclear cells.

Pub. Date : 1987 Sep

PMID : 3040807






1 Functional Relationships(s)
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1 Studies of the mechanism of suppression revealed (a) a classical opioid receptor is involved (suppression was antagonized by naloxone and was specific for the NH2 terminus of beta-END), (b) monocytes are the primary target cell for opioids (monocyte-depleted lymphocyte preparations showed little suppression), and (c) reactive oxygen intermediates (ROI) and prostaglandin E2 are important mediators (scavengers of ROI and indomethacin eliminated the suppression). Indomethacin proopiomelanocortin Homo sapiens