Title : Supplementation of p-coumaric acid exhibits chemopreventive effect via induction of Nrf2 in a short-term preclinical model of colon cancer.

Pub. Date : 2019 Nov

PMID : 30407216






1 Functional Relationships(s)
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1 1,2-dimethylhydrazine-administered rats supplemented with p-CA showed downregulation of the expression of colonic proteins, namely, cyclin B1, cdc2, and mdm2, which regulate cell cycle, and immediate early response genes, namely, c-fos, c-jun and c-myc, which regulate cell proliferation. 1,2-Dimethylhydrazine MYC proto-oncogene, bHLH transcription factor Rattus norvegicus