Pub. Date : 2018 Nov
PMID : 30405800
3 Functional Relationships(s)Download |
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Sentence | Compound Name | Protein Name | Organism |
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| 1 | Low dose dinaciclib enhances doxorubicin-induced senescence in myeloma RPMI8226 cells by transformation of the p21 and p16 pathways. | Doxorubicin | H3 histone pseudogene 16 | Homo sapiens | ||
| 2 | Furthermore, DOX resulted in increased alterations in DNA damage-related proteins such as p-ATM, p-Chk2, p-p53, p21 and gammaH2AX, but not p16. | Doxorubicin | H3 histone pseudogene 16 | Homo sapiens | ||
| 3 | Notably, the combination of dinaciclib and DOX inhibited cell growth and promoted senescence by transforming the suppressive effects of the ATM/Chk2/p53/p21 signaling pathway and enhancing the p16 signaling pathway. | Doxorubicin | H3 histone pseudogene 16 | Homo sapiens | ||