Pub. Date : 2018 Nov 30
PMID : 30404920
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Polyamine synthesis as a target of MYC oncogenes. | Polyamines | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 2 | ODC and polyamine levels are often up-regulated and contribute to tumor hyperproliferation, especially of MYC-driven cancers. | Polyamines | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 3 | We discuss the regulation of ODC and polyamines, which besides their well-known interactions with DNA and tRNA/rRNA, are involved in regulating RNA transcription and translation, ribosome function, proteasomal degradation, the circadian clock, and immunity, events that are also controlled by MYC proteins. | Polyamines | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |